Aralen (Chloroquine) is an antimalarial drug. Due to the inhibitory effect on the synthesis of nucleic acids, this drug has a moderately expressed immunosuppressive and non-specific anti-inflammatory effect. It causes the death of erythrocyte forms of all types of plasmodia.
It is active against Plasmodium falciparum, Plasmodium ovale, Plasmodium vivax, Plasmodium malariae, as well as against Entamoeba histolytica.
- Individual prophylaxis and treatment of all types of malaria;
- Extraintestinal amebiasis;
- Chronic and subacute forms of systemic lupus erythematosus;
- Rheumatoid arthritis, photodermatosis.
The dose is defined individually, depending on the indications and age of the patient. It is applied according to special schemes.
- Digestive system: nausea, vomiting, diarrhea.
- Central nervous system: dizziness, headache, sleep disturbances, psychoses, convulsive seizures.
- Dermatological reactions: discoloration of the skin and hair, dermatitis, photosensitivity.
- Hemopoietic system: thrombocytopenia, neutropenia, anemia, agranulocytosis.
- Cardiovascular system: rarely – myocardial damage with ECG changes, decreased blood pressure.
- Allergic reactions: skin rash, itching.
- Visual impairment;
- Hypersensitivity to chloroquine.
Simultaneous use of chloroquine with digoxin increases the letter concentration in the blood plasma. There is a significant decrease in metabolism and excretion of chloroquine when taking cimetidine. There is a decrease in its absorption when taking with ampicillin.
The simultaneous use of chloroquine with phenylbutazone, gold preparations, penicillamine, cytostatics, levamisole, there is the risk of developing bone marrow aplasia and skin damage.
Aralen (Chloroquine) is used with caution in cases of glucose-6-phosphate dehydrogenase deficiency, impaired liver and/or kidney function, porphyria, psoriasis, and epilepsy.
During treatment, systematic ophthalmological examinations and a general blood test are mandatory to undergo.
Intravenous introduction of chloroquine should be carried out slowly, in order to avoid the development of cardiotoxic effects.