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Kaletra (Lopinavir/Ritonavir)

Select Doses: 60tab

60tab
1bottle
Kaletra $337.19
$280.99
$280.99 per bottle
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60tab
2bottles
Kaletra $632.39
$526.99
$263.50 per bottle
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60tab
3bottles
Kaletra $862.79
$718.99
$239.66 per bottle
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Generic Kaletra is an antiviral drug. The active components of this drug lopinavir and ritonavir. Lopinavir inhibits the HIV protease (human immunodeficiency virus). Ritonavir inhibits the metabolism of lopinavir in the liver. It helps to increase the concentration of lopinavir in the blood. The suppression of HIV proteases results in the formation of a defective virus incapable to spread the infection all over the body.

Indications for generic Kaletra use

Generic Kaletra is prescribed as the complex therapy of AIDS (HIV infection) in adults and children over 3 years old.

How to take Kaletra?

These Kaletra tablets are taken orally without chewing. It is taken irregardless of food intake. The recommended dose of generic Kaletra is 2 tablets (400/100 mg) twice a day. Patients with no more than two mutations or with the development of resistance to the drug should take 4 tablets (800/200 mg) once a day.

Children with the weight over 35 kg are recommended to take Kaletra tablets in dosages of 100 mg + 25 mg. It is preferable to take the drug in the form of a solution of 80 mg + 20 mg/ml for children under 3 years of age.

Is overdose possible when taking this medicine?

There are no sufficient and reliable data and clinical experience of an acute overdose of HIV-infected patients when taking Kaletra.

What should I tell my doctor before taking this medicine?

  • Hypersensitivity to the drug;
  • Children under 3 years of age;
  • Severe liver failure developed as a result of cirrhosis or after infection with viral hepatitis C and B;
  • Pancreatitis;
  • Hemophilia;
  • Age over 65 years old;
  • Pregnancy;
  • Lactation.

Side effects

  • Hyperglycemia, a triglycerides and total cholesterol increase in plasma;
  • Anemia, lymphadenopathy, leukopenia;
  • Hypothyroidism, Cushing’s syndrome;
  • Dehydration, vitamin deficiency, milk acidosis, obesity, impaired glucose tolerance, weight loss and peripheral edema;
  • Sleep disturbances, amnesia, anxiety, agitation, ataxia, depression, orientation disorders, dyskinesia, dizziness, emotional lability, insomnia, encephalopathy, decreased libido, neuropathy, nervousness, peripheral neuritis, paresthesia, drowsiness, tremor, disturbances in thinking processes;
  • Otitis media, tinnitus, visual impairment, taste changes;
  • Tachycardia, arterial hypertension, vasculitis, thrombophlebitis;
  • Bronchitis, pulmonary edema, shortness of breath, sinusitis;diarrhea, cholecystitis, constipation, anorexia, dry mouth, dysphagia, dyspepsia, enterocolitis, belching, gastritis, flatulence, gastroenteritis, hemorrhagic colitis, pancreatitis, sialadenitis, increased appetite, ulcerative stomatitis;
  • Acne, dry skin, alopecia, dermatitis, maculopapular rash, furunculosis, skin itching, changes in the structure of nails, excessive sweating, benign skin tumors;
  • Arthrosis, myalgia, arthralgia;
  • Nephrolithiasis, urination disorders, premature ejaculation, gynecomastia;
  • Retrosternal pain, swelling of the face, fever, chills, general malaise, flu-like syndrome.

Interactions

  • It is absolutely contraindicated to use generic Kaletra simultaneously with drugs in which the clearance depends on CYP3A metabolism: Astemizole, Midazolam, Blonanserin, Terfenadine, Cisapride, Triazolam, Rifampicin, Pimozide, Voriconazole, Salmeterol, Vardenafil, alkaline amines, Ergoterin. Kaletra can lengthen or enhance their therapeutic effects, as well as side effects.
  • Kaletra can not be taken simultaneously with Propafenone and Flecainide, whose metabolism depends on the activity of CYP2D6. Such an increase in the blood concentration can cause life-threatening side effects.
  • Kaletra reduces the concentration of Abacavir and Zidovudine in the blood.
  • Didanosine must be taken 1 hour before or 2 hours after taking Kaletra.
  • The concomitant use with nevirapine, the concentration of lopinavir decreases.
  • Concentrations of antiarrhythmic drugs (Lidocaine, Bepridil, Quinidine) may increase in the case of the simultaneous administration with Kaletra.
  • Hypericum perforatum and Rifampicin reduces the concentration of lopinavir in the blood, which significantly reduces the therapeutic effect of Kaletra and contributes to the development of resistance of the latter.
  • The simultaneous administration with Kaletra, warfarin concentrations may vary.
  • Phenobarbital, carbamazepine, phenytoin (antiepileptic drugs) reduce lopinavir concentration.
  • It is necessary to use additional alternative methods of contraception while taking Kaletra and estrogen-containing contraceptives.