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What is Plaquenil – Uses, Side Effects, and Precautions

Short general description of Plaquenil

Plaquenil (generic name: hydroxychloroquine) is a medication that is commonly prescribed for the treatment of certain autoimmune diseases, such as rheumatoid arthritis and lupus. It belongs to a class of drugs called antimalarials, which are primarily used for preventing and treating malaria infections. However, Plaquenil has also shown efficacy in managing various autoimmune conditions.
Plaquenil works by suppressing the immune system and reducing inflammation in the body. It is believed to inhibit certain chemical processes involved in the immune response, thereby controlling the symptoms of autoimmune diseases. This medication is available in tablet form and is usually taken orally.
One of the main advantages of Plaquenil is its relatively good safety profile, making it a preferred choice for long-term treatment. Despite being an immune suppressant, it is generally well-tolerated by most patients. However, like any medication, Plaquenil may cause side effects in some individuals. These can include gastrointestinal issues, skin rashes, and changes in vision. It is important to discuss any potential side effects with a healthcare provider.
Studies have shown that Plaquenil can be effective in reducing the symptoms and progression of rheumatoid arthritis and lupus. It can help to control joint pain, swelling, and stiffness, as well as reduce the risk of complications associated with these conditions. Additionally, Plaquenil has been used off-label for other autoimmune disorders, such as Sjogren’s syndrome and dermatomyositis, with varying degrees of success.
It is worth noting that the use of Plaquenil in the treatment of COVID-19 has gained significant attention during the global pandemic. While initial studies suggested potential benefits, subsequent research has not provided conclusive evidence of its effectiveness in treating or preventing COVID-19. As a result, the use of Plaquenil for COVID-19 is not recommended by most healthcare authorities and professional organizations.
It is important to mention that Plaquenil should only be taken under the guidance and supervision of a healthcare professional. They will assess the individual’s specific condition and determine the appropriate dosage and duration of treatment. Regular monitoring may be required to ensure the medication is effective and well-tolerated.
In summary, Plaquenil is a medication used to treat various autoimmune diseases, primarily rheumatoid arthritis and lupus. It works by suppressing the immune system and reducing inflammation. While it has shown efficacy in managing these conditions, its use for COVID-19 is not recommended. As with any medication, it is important to discuss its benefits and potential risks with a healthcare provider.

Use of Plaquenil for COVID-19 Treatment and Prevention

Plaquenil (generic name: hydroxychloroquine) is a medication that has gained attention for its potential use in treating and preventing COVID-19. While originally developed to treat malaria, Plaquenil has also been used for other conditions such as rheumatoid arthritis and lupus.

1. Treatment of COVID-19:

Plaquenil has been suggested as a treatment option for COVID-19 due to its potential antiviral properties. It is believed to interfere with the viral replication process, making it harder for the virus to spread within the body. Some studies have shown that Plaquenil may be beneficial in reducing the severity and duration of symptoms in patients with COVID-19.

One study conducted in France found that patients who received a combination of Plaquenil and azithromycin (an antibiotic) had a significantly lower viral load compared to those who did not receive the treatment. However, it is important to note that the study had a small sample size and more research is needed to confirm these findings.

2. Prevention of COVID-19:

In addition to its potential as a treatment option, Plaquenil has also been explored for its use in preventing COVID-19 infections. It is believed that Plaquenil may be effective in preventing the entry of the virus into cells, thereby reducing the risk of infection.

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One study conducted in China evaluated the use of Plaquenil as a prophylactic measure in healthcare workers who were at high risk of exposure to COVID-19. The study found that those who took Plaquenil had a lower risk of developing the virus compared to those who did not take the medication. However, further studies are needed to confirm these findings and determine the optimal dosage and duration of treatment for prevention purposes.

3. Safety and Side Effects:

While Plaquenil may hold promise for the treatment and prevention of COVID-19, it is important to consider the safety and potential side effects of the medication. Common side effects of Plaquenil include nausea, diarrhea, and headache. In rare cases, more serious side effects such as heart rhythm problems and eye damage have been reported.

It is crucial to consult with a healthcare professional before starting any new medication, including Plaquenil. They can assess your individual risk factors, discuss potential side effects, and monitor your response to the medication.

4. Conclusion:

Plaquenil is a medication that has shown potential for the treatment and prevention of COVID-19. While early studies have shown promising results, more research is needed to fully understand its effectiveness and safety profile. It is important to rely on authoritative sources of information and consult with healthcare professionals for guidance on the use of Plaquenil for COVID-19.


Uses of Plaquenil

Plaquenil, also known by its generic name hydroxychloroquine, is a medication primarily used to treat malaria. However, it is also prescribed for several other conditions.


Plaquenil is widely recognized as an effective treatment for malaria. It works by killing the parasites that cause the disease, preventing the infection from spreading further in the body. Many clinical trials and studies have confirmed its efficacy in combating malaria.


Plaquenil is commonly prescribed for lupus, an autoimmune disease that causes inflammation in various parts of the body. It helps to decrease pain, swelling, and joint stiffness in lupus patients. Clinical trials have shown that Plaquenil can have significant benefits for those living with lupus.

Rheumatoid Arthritis

Plaquenil is frequently used as a disease-modifying antirheumatic drug (DMARD) to manage symptoms of rheumatoid arthritis. It can help reduce pain, inflammation, and morning stiffness associated with this chronic inflammatory condition. Research has demonstrated the effectiveness of Plaquenil in improving the quality of life for individuals with rheumatoid arthritis.

Sjögren’s Syndrome

Plaquenil is sometimes prescribed for Sjögren’s syndrome, an autoimmune disorder that affects the salivary glands and tear ducts, leading to dry mouth and eyes. It can help alleviate symptoms such as dryness and increase saliva production. Studies have shown positive outcomes in patients using Plaquenil for Sjögren’s syndrome.

Other Uses

In addition to the above conditions, Plaquenil can also be used off-label for several other purposes. These include certain skin disorders like cutaneous lupus erythematosus and dermatomyositis. It is also occasionally prescribed for certain types of porphyria, a group of rare genetic disorders affecting the nervous system or skin.

It is worth noting that Plaquenil should always be used as prescribed by a healthcare professional. Adherence to the prescribed dosage and regular medical check-ups are important to ensure its safe and effective use.

4. Side effects of Plaquenil

Plaquenil may cause several side effects, although not everyone experiences them. It is essential to understand these potential side effects before starting Plaquenil treatment. Common side effects include:

  • Nausea and vomiting: Plaquenil can sometimes cause stomach upset, leading to nausea and vomiting. It is advisable to take this medication with food to reduce the chances of experiencing these side effects.
  • Headache: Some individuals may experience headaches while taking Plaquenil. If the headaches persist or become severe, it is important to consult a healthcare professional.
  • Dizziness: Plaquenil can occasionally cause dizziness. It is recommended to avoid activities that require mental alertness, such as driving or operating heavy machinery, if dizziness occurs.
  • Ringing in the ears: A rare side effect of Plaquenil is tinnitus, characterized by a ringing or buzzing sound in the ears. If this occurs, it is advisable to notify a healthcare provider.
  • Changes in vision: Plaquenil has the potential to cause changes in vision, such as blurred vision or light sensitivity. Regular eye exams are necessary while on Plaquenil to monitor any changes in vision.
  • Mood changes: In some cases, Plaquenil may lead to mood swings, depression, or anxiety. If these symptoms occur or worsen, it is important to discuss them with a healthcare professional.
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It is crucial to report any side effects experienced while taking Plaquenil to a healthcare provider. In rare cases, Plaquenil may cause serious side effects, such as damage to the retina or heart problems. Therefore, regular medical check-ups and monitoring are necessary for individuals who are prescribed this medication.

“According to a study conducted by the American College of Rheumatology, about 10% of Plaquenil users may experience retinal toxicity, which could lead to vision loss if not detected early and managed properly”.

The recommended dose of Plaquenil varies depending on the condition being treated. It is important to follow the prescribed dosage and consult a healthcare professional for any concerns or questions regarding the medication.

For a comprehensive list of possible side effects of Plaquenil, consult the official medication guide provided by the manufacturer or seek guidance from a healthcare provider.

5. Side effects

While Plaquenil can be effective in treating various conditions, it is important to be aware of the potential side effects that may occur. Some of the common side effects include:

  • Headache
  • Nausea
  • Vomiting
  • Abdominal pain
  • Loss of appetite

In some cases, Plaquenil can also cause more serious side effects. These may include:

  • Allergic reactions, such as skin rash or hives
  • Dizziness or lightheadedness
  • Muscle weakness
  • Hearing loss or ringing in the ears
  • Vision changes or vision loss
  • Mood changes, such as anxiety or depression
  • Irregular heartbeat

It is important to immediately seek medical attention if you experience any severe side effects while taking Plaquenil.

Additionally, while rare, there have been reports of more serious side effects associated with long-term use of Plaquenil. These may include:

  • Damage to the retina of the eye
  • Muscle weakness or paralysis
  • Blood disorders
  • Liver damage

Regular monitoring and eye exams are recommended for patients on long-term Plaquenil therapy to detect any potential complications.

It is important to note that the occurrence of side effects may vary from person to person. Some individuals may experience no side effects at all, while others may experience multiple side effects. It is crucial to discuss any concerns or potential side effects with your healthcare provider before starting Plaquenil.

Overall, Plaquenil is considered a well-tolerated medication, and the benefits of treatment often outweigh the risks of potential side effects.

6. Side Effects of Plaquenil:

Although Plaquenil is generally considered safe and well-tolerated, it may cause side effects in some individuals. It is important to be aware of these potential side effects and consult with your healthcare provider if you experience any unusual symptoms.

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The most common side effects of Plaquenil include:

  • Headache
  • Nausea
  • Dizziness
  • Vomiting
  • Stomach cramps
  • Loss of appetite

In rare cases, Plaquenil can lead to more serious side effects. These include:

  • Changes in vision or blurred vision
  • Hearing loss or ringing in the ears
  • Muscle weakness
  • Irregular heartbeat
  • Mental/mood changes, such as anxiety or depression
  • Allergic reactions, such as rash or itching

If you experience any of these severe side effects, it is important to seek immediate medical attention. Your healthcare provider will be able to assess your symptoms and determine the appropriate course of action.

It is worth noting that side effects of Plaquenil can vary among individuals. While some people may experience no side effects at all, others may develop mild or severe reactions. It is important to listen to your body and communicate any concerns or symptoms to your healthcare provider.

It is also recommended to have regular check-ups and eye exams while taking Plaquenil. This medication may rarely cause retinal damage, especially with long-term use. Regular monitoring can help detect any potential problems early on.

As with any medication, the benefits of Plaquenil need to be weighed against the potential risks. Your healthcare provider can help determine if Plaquenil is the right treatment option for you, taking into consideration your medical history and individual circumstances.


  1. NIH U.S National Library of Medicine. Hydroxychloroquine and Chloroquine Retinopathy: Recommendations on Monitoring
  2. Mayo Clinic. Hydroxychloroquine (Oral Route) Side Effects

7. Side effects of Plaquenil:

Plaquenil, like any medication, may cause side effects in some individuals. It is important to be aware of these potential side effects and to consult with a healthcare professional if they occur.

Common side effects

Some of the commonly reported side effects of Plaquenil include:

  1. Stomach cramps or pain.
  2. Nausea and vomiting.
  3. Diarrhea.
  4. Loss of appetite.
  5. Headache.
  6. Dizziness or lightheadedness.
  7. Ringing in the ears.

It is worth noting that these side effects are generally mild and tend to improve with continued use of the medication. However, if any of these symptoms persist or worsen, it is important to seek medical attention.

Less common side effects

In addition to the above-mentioned common side effects, Plaquenil may also cause less common side effects, which could include:

  • Changes in skin pigmentation.
  • Hair loss or hair color changes.
  • Muscle weakness.
  • Nervousness or irritability.
  • Drowsiness.
  • Blurred vision or other visual disturbances.

These less common side effects should be reported to a healthcare professional if they occur, as they may require further evaluation.

Serious side effects

While rare, Plaquenil has the potential to cause serious side effects. These may include:

  • Allergic reactions, such as rash, itching, or swelling of the face, tongue, or throat.
  • Severe stomach or abdominal pain.
  • Muscle weakness or coordination difficulties.
  • Mental/mood changes, such as anxiety or depression.
  • Hearing loss.
  • Irregular heartbeat or other heart problems.

If any of these serious side effects occur, immediate medical attention should be sought.
It is important to note that this is not an exhaustive list of side effects, and other side effects may occur. Additionally, individual experiences with the medication can vary. It is always advisable to consult with a healthcare professional for personalized guidance and to report any side effects experienced during treatment.
1. Mayo Clinic. (n.d.). Hydroxychloroquine (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/hydroxychloroquine-oral-route/side-effects/drg-20064216
2. MedlinePlus. (2021). Hydroxychloroquine. Retrieved from https://medlineplus.gov/druginfo/meds/a601240.html

Category: Anti Viral

Tags: Plaquenil, Hydroxychloroquine

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